Examples of phenytoin

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In the case of phenytoin, there is an increased plasma half-time.
Phenytoin can be used once daily, which is an advantage in the case of patients requiring help from others with their medication.
The commonest polytherapy combination was phenytoin with phenobarbital.
This is particularly important with phenytoin, where different preparations have markedly different bioavailability.
In presence of refractory eclampsia, benzodiazepine and phenytoin are the drugs of choice.
The initial dose of phenytoin in an elderly person should not be more than 200 mg, possibly lower.
This has been demonstrated in the case of phenytoin, sodium valproate, and certain benzodiazepines.
There is also the question of drug-disease interactions, which may be a particular problem with phenytoin.
Phenytoin may be taken in a single daily dose55 - an advantage in those patients who depend on others to help with their medication.
Fosphenytoin (at a dose of 150 phenytoin-equivalent/min iv), which is metabolized to phenytoin, is associated with less maternal hypotension and bradycardia.
Guzman et al53 compared the effects of maternally administered phenytoin and magnesium sulfate on the fetal heart rate tracing using computer analysis.
Folic acid may also decrease levels of phenytoin and phenobarbital.
The teratogenicity of several anticonvulsant medications, including phenytoin, is associated with an elevated level of oxidative metabolites in the foetus that are normally eliminated by the enzyme epoxide hydrolase.
Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin.
Most patients gain symptomatic relief from carbamazepine, phenytoin or lamotrigine.
The two principal anticonvulsants used in treating epilepsy are phenytoin and phenobarbitone.
It is decreased in smokers and chronic alcoholism and by drugs such as phenytoin, carbamazepine, rifampicin and barbiturates.
Alternatively oxcarbazepine, phenytoin, clonazepam, sodium valproate or gabapentin can be added.
Phenytoin, one of the older antiepileptic drugs can result in an occasionally symptomatic, axonal, sensorimotor neuropathy which improves after withdrawal.

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