| 词汇 | example_english_adenovirus |
| 释义 | Examples of adenovirusThese examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter. Although animals were injected with the same amount of recombinant adenovirus, the level of expression detected depended on the individual promoter activity. Because adenovirus is a commonly occurring virus, most humans are pre-primed to at least one specific serotype. Repeated administration of a therapeutic adenovirus must be performed, which could result in an inflammatory response in the patient. Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapy. The other viral outbreaks (rotavirus and adenovirus) were all transmitted by person-toperson contact. Image reconstruction reveals the complex molecular organisation of adenovirus. Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice. The ferritin transgenes were delivered using a replicative-deficient adenovirus. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. An optimal animal model of the immunological challenges associated with human clinical trials for gene therapy would involve immunization with a wild-type, replicating, human adenovirus. Replication-defective recombinant adenoviruses are the second most commonly used viral vectors in clinical trials today. First-generation adenovirus can be engineered with powerful promoters to drive expression of therapeutic transgenes. Nonintegrating viruses, like adenoviruses, have the disadvantage that they remain episomal and can be lost during cell division. For the systemic immunization to eliminate transgene expression from the brain, >16107 infectious units (iu) of adenovirus need to be used as immunogen. In these studies we determined the dose of adenovirus needed for systemic immunization to eliminate transgene expression from the brain. To date, 47 serotypes of adenovirus have been characterised, and have been associated with a variety of symptoms ranging from a mild cold to acute febrile pharyngitis. Some altered adenoviruses have specific deletions in their genome to render them replication incompetent, whereby infection is abortive and no amplification and spread of the adenoviral agent occurs. First-generation adenovirus are powerful vectors for gene transfer into the brain in vitro and in vivo, and are employed currently in clinical trials for gene therapy. For gene therapy in almost all cell types both in vivo and ex vivo, the transduction efficiency of adenoviruses is high compared with that of other viral vectors. Outbreaks of adenovirus-associated respiratory disease have been more common in the late winter, spring, and early summer; however, adenovirus infections can occur throughout the year. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Some children (especially small ones) can develop adenovirus bronchiolitis or pneumonia, both of which can be severe. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Because there is no virus-specific therapy, serious adenovirus illness can be managed only by treating symptoms and complications of the infection. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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