Examples of thrombin

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We did not use thrombosis promoting methods, such as soaking the device in topical thrombin, to encourage rapid complete occlusion.
Ximelagatran acts by binding directly to free and clot-bound thrombin, thereby preventing the conversion of fibrinogen to fibrin, the primary component of blood clots (28).
Its main role is in coagulation; it is cleaved by thrombin to form fibrin.
This reaction provides an extremely strong activation of thrombin at the site of tissue damage, leading to the formation of a stable fibrin network.
Ximelagatran is the first oral representative from a new class of anticoagulants called direct thrombin inhibitors (18).
The human complement system in thrombin mediated platelet function.
The blood-coagulation cascade involves the sequential activation of pro-enzymes ultimately resulting in thrombin activation, which in turn cleaves fibrinogen into fibrin.
These results are consistent with some, but not all, aspects of previously reported results using non-pharmaceutical-grade thrombin preparations.
However, the mechanism of thrombin-induced protection remains unclear.
During bypass endothelial cells produce tissue plasminogen activator,21 probably in response to small quantities of circulating thrombin (not proven).
We recently demonstrated that pharmaceutical-grade recombinant human -thrombin (rh-thr) also induces a restricted set of proteolysis-dependent changes in microglial physiology.
Therefore, inhibition of thrombin activity is of central importance to blood feeders.
The local production of thrombin might explain the fibrin deposition observed during acute liver injury.
In vivo thrombin inhibition enhances and sustains arterial recanalization with recombinant tissue-type plasminogen activator.

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