phrase formal C1 to disagree strongly: 对…持强烈异议，很不赞同 I took issue with him over his interpretation of the instructions.我不赞同他对命令的理解。 She takes issue with the main premise of his article. I must take issue with a comment you made yesterday. Many scientists took issue with their research methods. They took issue with the idea that humans have a right to meddle with animals' genes. See also
issuenoun(SUBJECT)
take issue with someone/something | American Dictionary
take issue with someone/something
idiom to disagree strongly with someone or something: I take issue with parents who push their children too hard.