Examples of ribavirin

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Furthermore, we analyzed a worst-case scenario using extremely conservative estimates for benefits and costs for the combination therapy with peginterferon and ribavirin.
Severe adverse events may occur more frequently in patients treated with peginterferon plus ribavirin than in patients treated with interferon plus ribavirin (18;32).
This systematic review showed that combination therapy (interferon alpha and ribavirin) is better than interferon alone and that it is cost-effective.
Antiviral treatment (interferon alpha with or without ribavirin) was prescribed to 690 patients (38 %).
In summary, the available data (1;4) cannot support the superiority of therapy with peginterferon and ribavirin over conventional therapy with interferon and ribavirin.
The average daily dosages of prednisolone equivalents and ribavirin were high, 110 and 1200 mg respectively.
Therefore, combination therapy with peginterferon plus ribavirin was the most effective treatment strategy and was more efficient than interferon plus ribavirin.
The question now is whether the combination of pegylated interferon and ribavirin should replace dual therapy with interferon alfa and ribavirin.
Therefore, peginterferon plus ribavirin was the most effective and cost-effective treatment strategy.
In all these studies, antiviral therapy with interferon plus ribavirin seemed to be reasonably cost-effective.
Ribavirin (1000 - 1200 mg/d) was administered orally in all patients, depending on body weight.
A meta-analysis of randomized clinical trials on the medical effectiveness of antiviral combination therapy with peginterferon plus ribavirin was performed using random and fixed effects models.
Recent therapeutic advances, including the combination of pegylated interferon alpha and ribavirin, have increased the rate of response to 45-80 %, depending on pre-treatment patient characteristics [7-10].
Peginterferon plus ribavirin is the most effective and efficient treatment among the examined options.
For patients with genotype 1, 48 weeks treatment was significantly more effective than 24 weeks, and standard ribavirin dose was significantly more effective than low dose.
Genotype 2 and 3 patients, therefore, did not achieve any greater benefit from 48 weeks treatment or from a higher dose of ribavirin.
Two controlled randomized multicenter studies (18;32) regarding medical efficacy of combination therapy with peginterferon and ribavirin compared with interferon plus ribavirin were identified and included.

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