Examples of levodopa

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Almost all patients will eventually require levodopa therapy and many will experience problems of motor fluctuations after the 'honeymoon period'.
Metabolism occurs principally by peripheral decarboxylation of levodopa in the gut but also in other tissues.
They have a number of theoretical advantages over levodopa.
Possible treatment by increasing the daily doses of levodopa.
Entacapone has a similar half-life to levodopa and is usually given with each levodopa dose.
In most cases, levodopa should be given no more than five times daily before alternatives are considered.
The objective of the trial was to assess the efficacy and tolerability of once daily ropinirole 24-h prolonged release as an adjunct to levodopa.
As the disease progresses, however, response more closely mirrors plasma concentrations of levodopa.
Many others, such as captopril, lithium, anticonvulsants, beta-blockers, propylthiouracil, levodopa and nifedipine have also been strongly implicated.
With advancing disease, the therapeutic window becomes progressively narrower until the dose of levodopa required to turn a patient 'on' inevitably causes dyskinesia.
Patients were then randomized to levodopa plus either selegiline or placebo.
This was as great an improvement as that seen after initiating levodopa therapy.
It is often necessary to add a small dose of conventional levodopa first thing in the morning as a 'kick start'.
To begin with, patients notice predictable 'wearing off ' of levodopa's effects towards the end of a dosage interval.
This can be managed by a reduction in the dose of levodopa.
To begin with, patients notice predictable 'wearing off' of levodopa's effects towards the end of a dosage interval.
In the elderly, levodopa is usually started at a dosage of 62.5 mg. twice or three times daily, increasing cautiously, depending on response.

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