Examples of lethality

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First, population-based methods focus on reducing the availability of means, for example by fitting catalytic converters in cars to reduce the lethality of exhaust fumes.
The more severe phenotypes result in embryonic or neonatal lethality, precluding analysis of anomalies associated with later development such as the development of the murine middle ear.
Here we describe studies using these deletion complexes to identify and initially characterize a novel embryonic lethal mutation within the tw73 haplotype, termed tw73lab (t, wild 73 lethality at birth).
Progress in understanding the molecular basis of infection has allowed us to identify such protective alleles and also to infer their lethality through a lack of homozygous neonates.
Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis.
However, the early lethality in the knockout mouse precluded analysis of its function in the kidney.
Further, these animals were characterized by a marked reduction in body weight and an increase in lethality.
The mutation is associated with fine dorsal striping in affected heterozygous females and prenatal lethality in males.
Higher doses resulted in frequencies close to that in unirradiated embryos, though considerable embryonic lethality was also evident at these doses.
However, several factors precludes a rigorous statistical analysis of the relationship between developmental lethality and the size of the inserted fragment.
This result excludes the possibility that a transplicing effect is involved in lethality.
It has an incidence as high as 1 : 250 in embryogenesis, but only 1 : 16,000 of live births due to intrauterine lethality.
The authors focus mostly on residual activity (lethality) and address both target and non-target effects.
The causal relationship between severe neutropenia and lethality is also rather weak.
When hatch was complete, individual progenies were scored for semi-sterility (> 30% late embryonic lethality).
We directly monitored the lethality of each genotype during adulthood on 2- and 7-day-old flies.
These mice had observable phenotypic effects that ranged from normal to abnormal - even lethality.
Furthermore, regardless of the potential lethality of the diagnosis, survivability requires chemotherapy.
In contrast, this overexpression is not associated with lethality or brain abnormalities in vivo, indicating dosage effects and the need of additional mutations.

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