Examples of lamotrigine

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The most common side effects of lamotrigine are dizziness, tremor, somnolence, nausea, and headache.
This was partly due to a lower rash rate with lamotrigine.
In some cases, as in the replacement of sodium valproate by lamotrigine, there is useful guidance from the manufacturers.
Lamotrigine patients also complained less frequently of somnolence.
However, lamotrigine has been well tolerated as long-term treatment in pediatric patients with epilepsy.
Both lamotrigine and lithium were significantly superior to placebo in this regard.
Perhaps the greatest evidence that glutamate modulation might be important in the pathophysiology of mood disorders comes from the clinical use of the anticonvulsant lamotrigine.
The addition of carbamazepine to lamotrigine decreases lamotrigine blood levels by 50 and 29%, respectively.
Most patients gain symptomatic relief from carbamazepine, phenytoin or lamotrigine.
Preliminary results on pregnancy outcomes in women using lamotrigine.
During its escalation phase, plasma lamotrigine levels may be subtherapeutic.
Slow titration of lamotrigine is recommended, and is associated with a lower risk of having a rash.
For depressed youth, the fact that lamotrigine is unlikely to cause sedation, tremor, or weight change at therapeutic doses is a major plus.
Patients taking concomitant valproate are also at increased risk for developing a rash, because valproate elevates lamotrigine levels.
Enthusiasm for lamotrigine for therapy of younger patients with bipolar depression has clearly outstripped the evidence of its efficacy.
Use of this strategy is currently on the upswing because of clinical experiences combining lamotrigine with standard mood stabilizers such as lithium and divalproex.
Both lamotrigine and lithium were superior to placebo in delaying time to intervention for any mood episode.
The incidence of rash was significantly higher in the lamotrigine groups (7%) compared with the placebo group.

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