Examples of placebo

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Eight hundred patients were randomized to tocopherol/placebo or deprenyl/placebo, in a 2 2 factorial design.
Additionally, quality of sleep improved significantly among those treated with either dose of quetiapine compared with placebo.
In the final assessment, both doses of quetiapine resulted in significantly higher response rates than placebo (58% versus 36.1%, p 0.001).
Patients were randomly assigned in blocks of two to either nimodipine (n 50) or placebo (n 51) and the allocation was concealed.
In this comparison, the active drug and placebo are allocated to different subjects randomly.
However, the comparison between robust responders to drug versus robust responders to placebo seems to reveal an important feature of selegiline's specific effects.
Nausea as an adverse event was infrequent and transient (affecting two subjects on placebo and one on sertraline).
Interestingly, one clinical trial involving quetiapine showed significant separation on treatment response but did not show separation from placebo on remission.
Patients were randomly assigned to receive rosiglitazone (4 mg daily; n 20) or matched placebo (n 10).
The dosing schedule began at 2.5 mg/day of liquid fluoxetine or placebo once a day for 1 week.
Both lamotrigine and lithium were significantly superior to placebo in this regard.
Early studies of lithium in bipolar depression have noted an advantage over placebo.
124 subjects enrolled in the deprenyl arm (placebo for tocopherol).
A randomized, placebo-controlled trial of sertraline in the treatment of night eating syndrome.
Discontinuation in placebo-controlled trials was significantly more common than in active controlled trials (48.1% versus 28.3%).
In visit 1 one placebo capsule was administered followed by two placebo capsules after 2 hours.
Patients who consent to a placebo-controlled trial at least know that they are subjects and that they can stop being subjects at any time.
Patients in a clinical trial often consent with the knowledge that they stand to receive either an experimental treatment or a placebo.
However, given the large number of treatments that have been proven effective, placebo-controlled trials are often unethical.
A doubleblind, randomized, placebo-controlled study of quetiapine as adjunctive treatment for adolescent mania.
To assess the toxicity of celecoxib compared to placebo in this setting.
Randomized placebo-controlled biomarker modulation trial using celecoxib in premenopausal women at high risk for breast cancer.
A randomized, double-blind, placebo-controlled, multi-centre phase 3 study to determine the treatment effect of denosumab in subjects with non-metastatic breast cancer receiving aromatase inhibitor therapy.
Also, no differences in side-effects were reported between experimental and placebo control.
Mechanism of constipation in older persons and effects of fibre compared with placebo.
Mean bladder volume at first involuntary cystometric contraction and maximum cystometric capacity was also increased with oxybutynin versus placebo.
If in doubt, and with the patient's consent, repeated n=1 trials, comparing active and placebo injections, may give the answer.
The lipid-lowering arm was stopped early because of a significantly lower instance of heart attack and stroke compared to placebo.
An early placebo-controlled45 study showed a large response-rate to placebo despite a well-established r un in procedure.
Compared with placebo, both donepezil treatment groups showed statistically significant improvement in cognition, global function and activities of daily living.
However, it is common knowledge that these fire brigade measures constitute placeboes.
In the case of chemotherapy, placebos and double-blind situations are usually employed to ensure that an observed effect is directly attributable to the treatment.
In cases of mild depression, use of antidepressants does not have a proven effect greater than placebos, while psychotherapy has.
The authors concluded that pediatricians and researchers think that using healthy children and placebos in trials was cause for concern.
If we require and consider only "compelling sound methodological reasons" (the first clause), the flexible use of placebos might be very dangerous mainly in resource poor countries.
The two main points in the controversy over ethical codes, at that time, were the standard of care during the trial and the use of placebos.
Whatever the reason, the decision to omit placebo led to ambiguity and inaction.
To what extent is the success of the training programme just a placebo effect?
Several (6/19) patients in the placebo group experienced a significant (>50%) improvement in their tender- and swollen-joint counts during the study.
The sample size was based on an assumed 10% placebo success rate.
The primary outcome was change in attribute scores until 90 days after patients were assigned to either treatment or placebo.
There was a statistically significant greater reduction in manic symptoms in the olanzapine group compared to the placebo group.
Only one study has examined the effectiveness of pharmacotherapy in a randomized, placebo-controlled design.
The placebo debate was characterized as having three distinct approaches and each were explored.
The contribution of desire and expectation to placebo analgesia: implications for new research strategies.
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