| 词汇 | example_english_conformation |
| 释义 | Examples of conformationThese examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. A novel scoring function for predicting the conformations of tightly packed pairs of transmembrane alpha-helices. Prospects for resolving the conformations and fate of polypeptide in the chaperonin reaction 251 11. Illustrations of the chromophore conformations at i2 are shown at the top. In accordance with the general focus of this review, we mainly describe polypeptide backbone conformations and lipid-protein interactions. Two overlapping conformations were found that all of seven active agonists had in common. The mutant monomeric proteins might exist in two sets of conformations: a properly folded nontoxic species and an aggregate-prone toxic form(s). The time-averaged conformations will be non-zero both in scalar bendedness and vector bendedness. Moreover, proteins that undergo allosteric rearrangements and have multiple stable conformations separated by small energy differences can be affected by lattice forces. The protein shell is built of 90 dimers which have two distinct but similar conformations. Efficient sampling of ligand orientations and conformations in free energy calculations using the l-dynamics method. The existence of such simple patterns to folding kinetics is owed to a global organization of the landscape of energies of protein conformations. Of course, there may actually be even more than two enzyme-substrate complex conformations on the reaction pathway, requiring an even more complex kinetic mechanism. The latter were estimated for fixing sidechain rotamers in conformations consistent with helical mainchain structures. Three different parameter sets were determined for both high- and low-energy conformations. Beyond the elucidation of several conformations, the method has allowed a more complete characterization of the structural transition. The ' ' structural genomics ' ' database will soon follow, yielding a catalog of conformations of a sampling of the planetary proteome. Evidence that a single peptide binds major histocompatibility complex in different conformations. Residues 10-22 and 30-40 have b-strand conformations, forming two separate in-register, parallel b-sheets. Ligand-selective receptor conformations revisited: the promise and the problem. The hydroxyl group conformations significantly affected the internal energies. Such adjustments of side-chain conformations have been observed in other systems. Other residues showed minimal changes in local conformations. Predicting the conformations of peptides and proteins in early evolution. Furthermore, simulated annealing does not provide well-defined conformations, but the different conformations that are observed are consistent with several possible hydrogen bond combinations. Obviously, from the first to the third method the simulated annealing protocols had to cope with progressively less realistic start conformations. The sampling properties of some distance geometry algorithms applied to unconstrained polypeptide chains : a study of 1830 independently computed conformations. Computation of sterically allowed proton-proton distances and statistical analysis of proton-proton distances in single crystal protein conformations. An unambiguous stereospecific assignment results if allowed conformations occur only for one of the two possible assignments. Both of these two conformations match extended forms of glutamate. Superimposed on these conformations is a rectangle showing the plane formed by the three binding moieties. The conformations of these regions, however, remain generally unexplored territory though low resolution models have been proposed for some of them. The two subunits assume different conformations and expose different surfaces to the solvent. Mechanism of stabilization of helical conformations of polypeptides by water containing trifluoroethanol. The analysis assumes that the appropriate conformations relevant to the solution conditions have been stabilized and characterized. Moreover, multiple conformations of residues and heavy atoms in the crystal structures may cause problems for calculating the theoretical scattering. Distance distributions were analyzed with respect to linker flexibility and conformations. Many proteins undergo largescale conformational movement, and some seem (based on single-molecule studies) to flicker between active and inactive conformations. Since two conformations were obtained, a second step was per formed to choose one of the conformations. Structural differences between solution and crystal conformations are likely to be observed with increasing frequency in the case of allosteric enzymes, complexes or larger assemblies. Alternative conformations of amyloidogenic proteins govern their behaviour. An additional parameter describing the ' occupancy ' of a particular atom is normally only refined for structures with alternate conformations or partially bound ligands. The structure reveals multiple side chain conformations, ordered as well as disordered water, partly reduced disulphide bonds, etc., showing that such phenomena can be detected also in crystallographic structures. Strain-dependent differences in b-sheet conformations of abnormal prion protein. However, this model fails to capture atomic displacement directed along a single direction (anisotropic displacements) or if the disorder is due to the superposition of multiple static conformations. Instead, a complete understanding of protein synthesis will require determining the structural and energetic landscapes of ribosomal conformations that give rise to thermodynamic and kinetic behaviors. Defining solution conformations of small linear peptides. Influence of multiple well-defined conformations on small-angle scattering of proteins in solution. The existence of these conformations had been suggested by a previous study of this trisaccharide and were, as well, populated during a 5 ns molecular dynamics simulation. As the crystal cools it can be energetically favorable for flexible side-chains, which are disordered at room temperature, to adopt well-defined conformations and form new lattice contacts. The problem of finding molecular conformations that are in agreement with certain geometrical restraints can always be formulated as one of minimization of a suitable objective or target function. Calculation of protein conformations by proton-proton distance constraints. Molecular dynamics simulations of peptide fragments from hen lysozyme : insight into nonnative protein conformations. Therefore, it appears that cytochrome c binds to bilayers in two different conformations which are characterized by similar secondary structures, but different amide hydrogen exchange rates. Alternative conformations of a nucleic acid four-way junction. The micelle solubilized peptide is not trapped in a number of specific structures but seems to be able to exchange rapidly between a number of closely similar conformations. The observed pattern of mobilities is interpreted in terms of a rapid exchange between approximately equal populations of parallel and anti-parallel conformations as shown, with strand polarities indicated for clarity. Ionic interactions and the global conformations of the hammerhead ribozyme. By doing this, all of the molecules overlapped at the three putative binding sites in energetically stable conformations with the best atomic fitting for the basic structural atoms. Intercalation conformations in single- and double-stranded nucleic acids. The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways. The suc1 study used w-value analysis to verify the conformations of the rate-limiting transition state for the folding-unfolding and for the intermediate state in the refolding. Both correspond to extended conformations of glutamate in which the oxygen attached to the terminal carboxyl group is far from the alpha carboxyl and the amine groups. Sampling protein conformations and pathways. An atlas of serpin conformations. Thus, the perturbation of conformation of substrate proteins by the various attached probes presents a significant problem. The most striking feature of this interaction is the complete disruption of the anticodon loop conformation. Further, it appears that the order of magnitude of internal force-resisting packaging is not very sensitive to the final conformation. Traditionally, a crystallographic model is constructed of primarily one conformation. When the crystal is warmed it may not revert completely to its original room-temperature conformation, and on re-cooling may gradually progress toward optimal repacking. Lysine 6-, 11-, and 48-linked chains form closed conformations. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Secondary structure focuses on minor conformations that develop as a result of the hydrogen bonding between the amino acid chain. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Optical isomers can have different detections thresholds since their conformations may cause them to be less perceivable for the human nose. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Application of a stress favors some conformations over others, so the molecules of the polymer will gradually flow into the favored conformations over time. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Similarly, the glucofuranose ring may assume several shapes, analogous to the envelope conformations of cyclopentane. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The barrier of rotation between staggered conformations of ethane is approximately 2.9 kcal/mol. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The initial selection of candidate parents is based on body weight at 6 weeks of age and conformation score. The domains are maintained using two indexes: one to indicate the current conformation and one to indicate the current transformation. The conformation corresponds to internal structure, as external factors can be simulated with the use of a set of rigid nucleotides. While the square conformation is predicted to be most stable under the low-salt conditions, this need not necessarily be planar. Mutations can cause large changes in the conformation of a denatured protein. The existence of specific conformations is due to hindered rotation around sigma bonds, although a role for hyperconjugation is proposed by a competing theory. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The crystal structure of tendamistat revealed an immunoglobulin-like fold that could potentially adopt multiple conformations. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Specific domains of the channel subunits have been identified that are responsible for voltage-sensing and converting between the open and closed conformations of the channel. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Dots correspond to model conformations and squares to crystallographic results. However, care must be taken as the crystal lattice can directly influence what conformations can be observed and what range of motions are possible. Restored linker conformations between the modules are displayed by a blue beads representation and varied from run to run. In this case, multiple possible conformations taking advantage of the now numerous adventitious contacts will be possible and the system will exhibit complex kinetics. The new conformations are stabilized by inter- and intramolecular hydrogen bonding. The conformations of the more distant ends of the b-strands and connecting turns are more poorly conserved. Until recently these two transitions were hypothetical voltage sensor conformations that were needed to account for the macroscopic channel behavior of delayed activation. Indeed, the scattering from a mixture of conformations is the sum of the various contributions weighted by their respective fractional concentration. The signal for activation is then conveyed in different ways in the different enzymes to the active sites, which can then adopt their catalytic conformations. The specificity is brought about by the minimum energy conformations of the complex geometries. Of particular interest in this context are the small all- - folds that assume conformations such as barrels or -helices. Once minimal energy conformations of all structures were in hand, the next step was to overlap the three charged groups in the seven agonists. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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