| 词汇 | example_english_chaperone |
| 释义 | Examples of chaperoneThese examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. The reason for this is that, at present, there is no k n o w n mechanism to explain how cells can secrete molecular chaperones. Therefore, pharmacological chaperones show great promise as a new class of therapeutic agents that can be specifically tailored for a particular genetic disease. A related strategy for the treatment of various protein-misfolding disorders is to rescue folding defects with 'pharmacological chaperones'. The processing defects must be identified and tested to determine whether they can be rescued with pharmacological chaperones. Are the effects of multiple pharmacological chaperones additive or synergistic? In some cases, chaperones promote the correct folding of their misfolded protein substrates. The girl of the period demands increased liberties, including the right to entertain without chaperones, to wear cosmetics, and to dress in stylish fashions. Thus, i t was possible that these findings were not d u e to the molecular chaperones themselves, b u t to contaminating bacterial components. Many researchers worldwide are attempting to determine the mechanism of action of these various molecular chaperones, many of which exist as families of related proteins. Initial clinical studies with pharmacological chaperones have successfully reduced clinical symptoms of disease. The advantages of pharmacological chaperones are that they can be specific and nontoxic, and can be used at much lower concentrations than chemical chaperones. Examples of processing mutants rescued by pharmacological chaperones are discussed below. Despite these potential problems, the initial cell culture and clinical studies suggest that pharmacological chaperones offer an exciting new therapeutic strategy to treat genetic diseases. Molecular chaperones in the cytosol : from nascent chain to folded protein. An open question is do such anti-parallel configurations exist in the physiological context and if so, are they regulated by chaperones ? However, it is the nature of release that particularly sets the chaperonin class apart from other chaperones. The observations outlined above suggest that enhancing the function of molecular chaperones might be a useful strategy to inhibit toxic aggregate formation in various proteinmisfolding diseases. At first sight, this knowledge gap seems to represent a significant p ro b l e m for those studying the cell-to-cell signalling properties of molecular chaperones. Review: mechanisms of disaggregation and refolding of stable protein aggregates by molecular chaperones. In principle, neither of the models for prion propagation rule out a possible assistance by molecular chaperones. Active solubilization and refolding of stable protein aggregates by cooperative unfolding action of individual hsp70 chaperones. The heat shock response : regulation and function of heat-shock proteins and molecular chaperones. Molecular chaperones in pancreatic tissue : the presence of cpn10, cpn60 and hsp70 in distinct compartments along the secretory pathway of the acinar cells. Therefore, one approach to promote folding of processing mutants would be to stabilise the mutant protein during the folding process through the use of chemical chaperones. Progress and perspectives on the biology of heat shock proteins and molecular chaperones. Not all chemical chaperones function as osmolytes. Molecular chaperones and the cytoskeleton. The general concept of molecular chaperones. There are no regulations which specifically govern the minimum age at which young people can work as models without chaperones. From the Hansard archive Example from the Hansard archive. Contains Parliamentary information licensed under the Open Parliament Licence v3.0 After rehearsal, activities are run by the chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. To increase the crystallization probability of a target molecule, nanobodies can be used as crystallization chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. In eukaryotic organisms chaperones are known as heat shock proteins. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Prolyl isomerases therefore function as protein folding chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. An adult chaperones the group but stays in the background of the performance. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Women from nearby colleges and towns would serve as chaperones to the men at cadet dances. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Initially, these proteins were thought to chaperone and refold molten proteins, or if this proved impossible to sequester and degrade them through the ubiquitination pathway. The protein is then free to fold on its own, or to be transferred to other chaperones for further processing. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Chaperones may be resisted and resented by the young people being supervised. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. One major function of chaperones is to prevent both newly synthesised polypeptide chains and assembled subunits from aggregating into nonfunctional structures. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The use of chaperones is intended to prevent the occurrence of violence and alcohol or drug use. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. While parents do not attend a formal, teachers act as chaperones for the formal and security guards are sometimes hired. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The chaperones also can change the conformation of the nucleosome as a whole. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. They donated tens of thousands of man-hours to restore her, maintained her at their own expense, and served as docents and chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Group programs are offered with over 30 public and private schools, university programs, and youth groups bringing 20 - 30 young people and their adult chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The presence of chaperones is universal, due to the obvious ethical impossibility of separating a very young child from all caregivers. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Chaperonins belong to a large class of molecules that assist protein folding, called molecular chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Her research is largely based around molecular chaperones and protein misfolding. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The expression of the molecular chaperone calnexin is decreased in cancer cells grown as colonies compared to monolayer. Homologous plant and bacterial proteins chaperone oligomeric protein assembly. Hop belongs to the large group of co-chaperones, which regulate and assist the major chaperones (mainly heat shock proteins). From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Enhancing chaperone function and stimulating aggregate clearance might be useful therapeutic strategies for the treatment of proteinmisfolding disorders. In this case, chaperones do not convey any additional steric information required for proteins to fold. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Although most newly synthesized proteins can fold in absence of chaperones, a minority strictly requires them for the same. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Various approaches have been applied to study the structure, dynamics and functioning of chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Other chaperones are involved in folding newly made proteins as they are extruded from the ribosome. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The common perception that chaperones are concerned primarily with protein folding is incorrect. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Does the chaperone heat shock protein hsp70 play a role in the control of developmental processes? The second rank was shared by the "ayas" (royal governess) and "guardas" (chaperones). From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. A large number of diseases, including degenerative neuromuscular disorders and cancer, are associated with dysfunction of molecular chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The tip of the chaperone's umbrella points in the direction the dancer must take; towards the stage and away from her guardian. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The students travel with a team of staff and chaperones including scientists, historians, artists, explorers, polar experts and others. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Rapidly growing cancer cells rely on specific chaperones, and some chaperones play key roles in chemotherapy resistance. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. A variety of gene components appear to be implicated, resulting in the formation of intracellular proteins known as "heat-shock" or chaperone proteins. The concentration of pharmacological chaperone required for rescue might be too high and produce side effects. Dbutantes and chaperones are planning their gala dinners - and the blackmailer is planning strategies to stalk his next victim. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. When secretion starts, the chaperones detach from the effectors and the latter are secreted and leave the cell. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. After a difficult start, he proves a surprise hit with the modern-day audience, especially the adult chaperones when they realize their girlhood idol is on-stage. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. He frequently chaperones at field trips and school events, is an avid rugby player and always refers to students by their last names. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Complex formation with the chaperone thus allows the correction of misfolded conformations in an isolated environment without the danger of intermolecular aggregation reactions. Enzymes called chaperones assist the newly formed protein to attain (fold into) the 3-dimensional structure it needs to function. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Phosphatidylcholine normally chaperones bile acids, preventing damage to the biliary epithelium. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Alternatively, disruption of the pathways to refold proteins (chaperones) or to degrade misfolded proteins (the ubiquitin-proteasome pathway) may lead to protein aggregation. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Negligent chaperones could be prosecuted under various laws, placing the blame on those who failed in their responsibilities as guardians rather than on the victim. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Valenti also takes her to the prom as chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. In some cases, the manservant assumed the place of the absent husband as chaperone. The assembly process is aided by scaffolding proteins, which act as chaperones. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Bulk biochemical measurements have informed us on the protein folding efficiency, and prevention of aggregation when chaperones are present during protein folding. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. One possibility is that the chaperone capacity of a-crystallin is overwhelmed by the large amount of mutant protein. A chaperone sat by the woman's side at such encounters. Further studies are necessary to understand why the chaperone activity of a-crystallin does not prevent in vivo hereditary cataract formation. The players were expected to be perfect ladies, as they had chaperones directing their every move. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Cell-lysate conversion of prion protein into its protease-resistant isoform suggests the participation of a cellular chaperone. Under physiological conditions, some of these proteins function as molecular chaperones or proteases that have a number of intracellular functions. The literature abounds with controversy about the roles of molecular chaperones in immunity. Pharmacological chaperones have to be identified that are nontoxic, show specificity and do not inhibit function of the protein once it has been rescued. Emphasis is placed on small molecules that inhibit protein aggregation, upregulate molecular chaperones, or interfere with downstream toxic pathways. Emerging data suggest that it may be possible to upregulate molecular chaperones using one of several pharmacological strategies. The modern nation states, the product of 1945 above all, the grown-up children of the empires, are breaking free from their chaperones. Structure and function of the small heat shock protein/ a-crystallin family of molecular chaperones. The 1990s were a period of enormous advancement in our understanding of the molecular, structural and cellular biology of the molecular chaperones. Molecular chaperones are involved in many essential cellular functions, such as metabolism, growth, differentiation and programmed cell death, through protein assembly and transport. Proteins that mediate these reactions, generally termed molecular (or nuclear) chaperones, have been identified biochemically. In this study we have found that a subset of these highly abundant proteins are molecular chaperones. They could, for example, be useful chaperones for women who wished to go to church for devotion or diversion. Although there are no known zinc chaperones, membrane transport and regulatory proteins specific for zinc have been identified in some organisms. Answers to these questions may enhance the therapeutic value of pharmacological chaperones. A potential therapy for protein misfolding is to correct defective protein folding and trafficking using pharmacological chaperones. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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