| 词汇 | example_english_binding-site |
| 释义 | Examples of binding siteThese examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. The findings are more consistent with a pathway than with a fixed bindingsite. The activity of cyclic nucleotide analogs is informative regarding the nature of the bindingsite and the structural requirements for ligand activity. We discussed both the classical approach, assuming distributed binding sites in a smeared layer and a one-binding-site model. Most lipocalins are beta-barrel structures with only one bindingsite for hydrophobic molecules. Once assembled, the terminal regions are folded to become the bindingsite for the next subunits. The nucleotide bindingsite is located in a pocket between the two domains. This analysis should quantitatively reflect the free energy surface sampled by the ligand as it is pulled through the bindingsite. More experiments investigating the nucleoside specificity of this bindingsite is under progression in our laboratory. Favorable positions of functional groups in a bindingsite can be found and even novel minima, which are not present in the fixed structure. These regions have been classified by the strength with which water is bound and the nature of the bindingsite. As documented above, one is where the short motifs overlap and combine to perform a single bindingsite. This is a strong argument for a bindingsite outside the pore. The charges are shown arranged nonspecifically to emphasize that such a mechanism is not dependent upon the existence of a specific bindingsite or pocket. Residues outside the bindingsite are represented by surface plot. A bindingsite identified by these assays, however, does not necessarily represent a functional target in vivo. Neighbouring residues of the minichaperone bindingsite are represented by white bonds. As already mentioned, long-range electrostatic fields due to charges either in or around the bindingsite sometimes extend several nanometers from the protein surface. Residues 152-385 have been omitted to show the nucleotide bindingsite with roughly twofold symmetry. This factor is correlation between the binding sequence preferences at different base-pair positions along a bindingsite. The structure showed a putative bindingsite, a cleft that was conserved in the modelled structures of homologues. Targeting of calmodulin to the microtubules is not affected by blocking the calcium-dependent bindingsite, while targeting of calmodulin to the nucleus is. The cytidylyltransferase superfamily : identification of the nucleotide bindingsite and fold prediction. Correlation can be detected by checking whether the sequence probabilities for multi-basepair fragments along a bindingsite are equal to the sum of the probabilities of the individual base-pair positions. A simple method for determination of affinity and bindingsite concentration in receptor binding studies. Detection of a larger, overlapping bindingsite such as this is a direct observation from regression trees. So much for what happens at the bindingsite of a variable. There has been much speculation regarding the position of the benzimidazole bindingsite on the tubulin molecule. Localization of the colchicine bindingsite of tubulin. The ligand bindingsite is made up of eight to ten leucinerich glycoprotein repeats. In addition, bindingsite changes typically require multiple mutations, presumably making them infrequent events. We propose a third modality involving the folding of a bindingsite or pocket in concert with the formation of long-range interactions in distal regions of the molecule. By mapping the ligandinduced perturbations onto the protein surface, the location of the bindingsite can be obtained. In summary, the movement of the -strands into the active site results in a dysfunctional bindingsite for catalytic divalent ions. Molecular localization of an ion bindingsite within the pore of mammalian sodium channels. Discovery of the ammonium substrate site on glutamine synthetase, a third cation bindingsite. Moreover, the residence time of bound water coincides with time scales for fluctuations of conserved side chains in the bindingsite. The aromatic bindingsite for tetraethylammonium ion on potassium channels. For the same reason, the absence of a consensus bindingsite does not rule out the possibility of being a target in vivo. Location of the transition metal bindingsite in the pore. Consequently, the presence of a bindingsite for a given transcription factor as measured by in vitro assays does not necessarily mean a true target in vivo. A useful observation from this work is that correlation, when it occurs, is generally only important at a limited number of positions along the bindingsite. The extent of this preferential partitioning defines both the specificity of the ligand for a single, unique site(s) on the receptor molecule and the selectivity of the bindingsite. In addition, some of the techniques allow the identification of the ligand bindingsite or which part of the ligand is responsible for interacting with the target. The bindingsite of the ribosome on the rough endoplasmic reticulum is the translocon. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Aminopterin works as an enzyme inhibitor by competing for the folate bindingsite of the enzyme dihydrofolate reductase. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. This channel is specific because it has a bindingsite for maltosaccharides. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Additionally, the ribosome bindingsite model is used to make the gene-start predictions more accurate. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The aligned region includes the flavin bindingsite of these enzymes. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Alternatively, the nucleosome can be partially unwrapped by thermal fluctuations allowing temporary access to the transcription factor bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. All known blockers compete for roughly the same bindingsite, the pore, in all subtypes. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. By integrating a large number of short reads, highly precise bindingsite localization is obtained. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. A common drug, diazepam, acts as an allosteric enhancer at this bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. It does not bind directly to the procaspase-9 bindingsite, but likely induces a conformational change that renders procaspase-9 binding less favorable. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The active bindingsite of an enzyme has a unique geometric structure that is particularly suitable for a substrate. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Upon binding, gp120 undergoes a conformational change, which causes the formation of the coreceptor bindingsite on gp120. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. For example, lysine acetylation may create a bindingsite for chromatin-modifying enzymes (or transcription machinery as well). From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Conformational deviations are primarily located in the four loops reaching in the ligand bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Mutagenesis of amino acids at the bindingsite allows for changing the affinity and selectivity. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Its sequence similarity to other toxins that can compete with the bindingsite of apamin is much lower. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. It contains a stem-loop structure upstream of a ribosome bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. With the bindingsite blocked, signal molecules can no longer attach there and activate the tyrosine kinase. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Mapping by mutagenesis of this domain has shown that amino acid residues 915 make up the receptor bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The structure of the bindingsite for the acetylcholine and nicotine was located at the interface between adjacent subunits. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The sequence creates the bindingsite for an amino acid. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. This is typically accomplished through chelation of the zinc bindingsite. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. These leftover calcium ions move around inside the sarcomere and may eventually find their way to a bindingsite on the thin filament's regulatory protein. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. In particular, it is important to know whether a nucleosome is covering a given genomic bindingsite or not. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Tyr385 makes for some sterical restrictions of this side of the bindingsite so a small substituent of the phenyl group makes for better binding. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. In virtually every case, competitive inhibitors bind in the same bindingsite as the substrate, but same-site binding is not a requirement. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The metal bindingsite of the toprim domain is where the primer is synthesized. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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