Examples of epistasis

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Several lines of evidence indicate the importance of epistasis.
For mutation-selection balance we confirm that increased recombination always evolves if, on average, epistasis is negative and weak.
When epistasis is sufficiently weak, increased recombination is always favoured under mutation-selection balance and never under migration-selection balance.
With weak migration, for recombination to increase also requires negative (synergistic) epistasis.
A simple model of the effect of synergistic epistasis on the inbreeding load is developed.
Natural populations will most likely have some epistasis.
However, the triploid progeny displayed more diverse genetic structures, with more contributions to the genetic variance by dominance and epistasis, than the diploid progeny.
Marker-based inferences about epistasis for genes influencing inbreeding depression.
Furthermore, one can distinguish between the effects of conversion and of a combination of epistasis and recombination.
On balance, the evidence for epistasis is weak.
There are theoretical arguments for the type of epistasis observed in this study.
By doing this, we hoped to evaluate further the importance of epistasis in chicken growth and to identify genetic mechanisms underlying detected epistasis.
Ordering gene-function : the interpretation of epistasis in regulatory hierarchies.
Here, we only concern ourselves with the case of negative epistasis because it allows straightforward comparisons with the analytical coalescent approach.
Based on simulations, they observe that recombination together with synergistic or diminishing epistasis increases or decreases permissible mutation rates and genome sizes.
The simulations showed that the power to detect epistasis is high and that it increases with the heritability.

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