Examples of conformational

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For molecules that bind to proteins, the restriction of conformational freedom is a natural consequence of binding.
The existence of a complex conformational landscape indeed underlies the discussion throughout this review.
In some cases, the modified protein has reduced conformational stability and therefore an increased propensity to misfold and aggregate.
A priori, these two components need not be separable : a single global conformational change might accomplish both changes.
However, these surfaces are entirely distinct as a result of the agonist-induced conformational changes.
The signature of a conformational change in the spectrum can then be used to detect and define transient conformational states of a protein.
These conditions may influence some lipid and protein conformational properties.
Work with cysteine substitution has helped to define the nature of the conformational change at the extracellular mouth.
Conformational preferences of four peptides spanning the sequence of hen lysozyme.
The binding or release of oxygen results in conformational changes that alter the affinity of haemoglobin for oxygen.
The effect of substrate, or substrate analogue, on the conformational state of the hexameric enzyme is clearly cooperative, with operation of quaternary constraints between monomers.
Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin.
Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling.
The following two sections review two proteins whose conformational behaviour with cosolvent have been extensively studied. 10.
The conformational problem is therefore likely to remain incompletely resolved for the foreseeable future.
A complete folding mechanism involves a complex network of such ' elementary' reaction events representing these conformational changes.
Consequently, the arginines are carried through the membrane electric field, resulting in a conformational change which couples channel opening to membrane voltage.
Indeed, effective responses to stimuli may require weak intrinsic affinities to assure sufficient interfacial plasticity for the expression of ligand-induced conformational changes.
As a detection reagent for biological substances, antibodies have the advantage of being conformational, rather than sequence-dependent.

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