词汇 | valproate |
释义 | BETA Examples of valproatevalproate isn’t in the Cambridge Dictionary yet. You can help! All three were treated with antipsychotic medication and sodium valproate as a mood stabilizer, two as in-patients, one as an out-patient. Patients taking concomitant valproate are also at increased risk for developing a rash, because valproate elevates lamotrigine levels. Common side effects of valproate in children and adolescents include nausea and vomiting, increased appetite, weight gain, sedation, thrombocytopenia, hair loss, and tremor. When the paradigm was changed to trace conditioning, there was no evidence of hippocampal dysfunction in the valproate-exposed rats. Further, valproate exposure shortened the brain stem, the same effect we saw in the human case. Repeated measures analyses were used to determine whether treatment with the valproate or tegretol influenced task performance. Although there was marginally better seizure control and there were fewer side-effects on sodium valproate, the differences were not statistically significant. It was also superior to valproate in elderly-onset seizures, which is what might be expected given that the latter are overwhelmingly partial or secondary generalized. In some cases, as in the replacement of sodium valproate by lamotrigine, there is useful guidance from the manufacturers. Both the volume of the nucleus and the number of neurons of the inferior olive are significantly reduced in the valproate model. The structures we had found to be damaged by the valproate exposure were not ones likely to affect the development of the cerebellum directly. In such cases, and in our present state of uncertainty, valproate should be the first drug of choice. This does not appear to apply to valproate. Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers. Second choices (in descending order) were carbamazepine, phenobarbital and valproate. Most of the patients in the study were treated with carbamazepine and valproate. The three principal mood stabilizers are lithium salt, carbamazapine, and valproate. This has been demonstrated in the case of phenytoin, sodium valproate, and certain benzodiazepines. Neurotoxicity may occur in hypoalbuminaemic states despite seemingly therapeutic levels of valproate. |
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