exhausted
We just left Egypt yesterday and we saw Petra today and are all very tuckered out!
Come on, let's go to bed. I'm tuckered.
Mice can gallop on rodent-sized treadmills for as long as six hours and cover more than three miles before they're tuckered out.
Around the region, totally tuckered hurricane warriors are fighting emotional and physical pain.

SMART Vocabulary: related words and phrases

Tired and making tired
all in
anti-fatigue
at your worstidiom
be dead on your feetidiom
be fit/ready to dropidiom
finish something off
fit to dropidiom
fragile
frazzled
gassed
haggard
knackered
shell-shocked
sleep deprivation
sleep-deprived
sleepily
sleepiness
sleepy
strung out
zonked