Examples of transferrin

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One approach has been to use serum transferrin receptor assay.
Care must be taken when using this measurement in the aged population, since many factors can affect serum transferrin levels.
Here, macrophages incorporate iron, which is then released from haemoglobin and passed to transferrin.
Circulating soluble transferrin receptors can be measured by radioimmunoassay and are in a dynamic balance with the bound receptors.
The transferrin then transports iron to the erythroid precursor cells in the bone marrow, where it is again incorporated into haem biosynthesis.
The measurement of transferrin receptors is more appropriate in these patients.
The surfaces of all iron containing cells have transferrin receptors that bind circulating transferrin.
Up to 30% of transferrin-bound iron is released to placental transferrin receptors.
Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin.
Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression.
In addition, two extreme values tested positive for the blood protein transferrin and were eliminated from the analyses.
The serum ferritin level should be maintained well above 100 ng/dl and transferrin saturation at 20%.
However, the transferrin receptor-ferritin index (the ratio of serum transferrin receptor level to log ferritin level) diagnosed iron deficiency in 43 of the 49 patients.
Further, erythroid transferrin receptors are down regulated.
Transferrin has a short half-life, and nutritional depletion may result in depressed levels of transferrin before any changes in the serum albumin can occur.
The detection of coexistent iron deficiency can be problematic, since in this situation the plasma transferrin and ferritin concentrations will reflect the underlying chronic disease, rather than the iron deficiency.

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