Examples of thiazide

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There was concern that the benefits of thiazides in the treatment of hypertension could be negated by their tendency to cause hypokalaemia.
With the exception of low-dose thiazide diuretics, the dose of drug needs to be titrated against the blood pressure response.
In summary, the author's view is that low-dose bendrofluazide (or other thiazide) should remain the first-line treatment.
Randomised study of six betablockers and a thiazide diuretic in essential hypertension.
Beta-blockers have been evaluated in outcome trials but are less effective than thiazides in preventing stroke9,10 for the same degree of blood pressure reduction.
The effect of beta-blockers on blood pressure is broadly similar to that of the thiazides.
The two placebo-controlled calcium antagonist trials show benefits which are broadly similar to the thiazide-based trials.
Low-dose thiazide is better tolerated and much more cost-effective.
Low glomerular filtration rate render thiazides ineffective, limiting their use in older people.
A low-dose thiazide is therefore preferred, but should it be given alone or in combination with a potassium-sparing agent?
Finally, impotence is a serious problem in younger men taking higher-dose thiazide treatment.
Much further research is necessary to determine the best drug to add to the thiazide diuretic when inadequate blood pressure control is achieved.
Beta-blockers are also often contraindicated in elderly hypertensives and cost considerably more than thiazides.
Further work might usefully assess if even smaller doses of thiazides than previously used might provide the same cardiovascular benefits with fewer adverse effects.
The theoretical benefits of calcium antagonists over thiazides have not been realized in practice.
Moreover, most of the trials showed no benefit in increasing the thiazide dose.
The authors therefore conclude that thiazide-type diuretics are superior in preventing one or more major forms of cerebrovascular disease.
Penicillins, cephalosporins, thiazides, furosemide, and diphenylhydantoin are oth123 ers.

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