| 词汇 | thalassaemia |
| 释义 | thalassaemia noun[ U ] medical UKspecialized(USthalassemia)uk /ˌθæl.əˈsiː.mi.ə/ us /ˌθæl.əˈsiː.mi.ə/ a medical condition of the blood in which haemoglobin (= the substance in red blood cells that combines with and carries oxygen around the body, and gives blood its red colour) is not produced in the normal way地中海贫血 Disorders & diseases of the heart & blood acidosis acquired agammaglobulinemia adult-onset diabetes afib agammaglobulinemia anaemic apoplexy clot-busting coarctation of the aorta congenital erythropoietic porphyria congestive heart failure coronary heart disease decompression sickness furred MEN1 syndrome MGUS mini-stroke mitral monoclonal gammopathy of unknown significance toxaemia Examples of thalassaemiathalassaemia Those associated with beta thalassaemia syndromes include complications related to osteoporosis and diabetes. The name of the thalassaemia re-ects the globin chain whose synthesis is either diminished or non-existent. As a general rule, patients with thalassaemia syndromes are at increased risk of iron overload. A blood film from a patient with the thalassaemia trait is largely indistinguishable from that of a patient with iron deficiency. Despite the plethora of muations in thalassaemia, some general points can be made. In severe forms of thalassaemia, patients are dependent on transfusions for survival. Below, we explore investigations into treatments that are being aimed at the underlying pathophysiology of thalassaemia, including new advances in chelation. Figure 1 represents the main mechanisms causing iron overload in thalassaemia. If the thalassaemia trait is present, younger family members may require genetic counselling. There was high-level transduction with a complete correction of the in vitro model of human thalassaemia erythropoiesis and in vivo in immune-deficient mice. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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