词汇 | serotonergic |
释义 | BETA Examples of serotonergicserotonergic isn’t in the Cambridge Dictionary yet. You can help! These findings raise the possibility of serotonergic influence on diurnal variation, and that the symptom of reversed diurnal variation is of relevance to antidepressant prescribing. Effects of serotonergic disturbances during development will hence differ from those in adulthood. Controlled studies of the effects of serotonergic agents on aggression in pediatric samples are few in number. Work to date has not focused on early stressors and serotonergic function - research is needed in this area. Given the various aetiological factors influencing the development of obesity, it is likely that some obese patients will respond better to serotonergic compounds than others. It is thus possible that aging enhances depressionassociated changes in serotonergic responsiveness. There is substantial evidence that serotonergic systems play an important role. These findings suggest that serotonergic pathways, in addition to affecting ingestive behaviour, may also regulate energy expenditure. Finally, future directions in the elucidation of serotonergic metabolic regulation are discussed. Further characterisation of serotonin neurons and serotonergic projections regulating energy balance and glucose homeostasis is an important area of future research. Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. To complicate matters further, the same serotonergic agonist may reduce or increase locomotor activity depending on the dose administered. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. This structural deviation may contribute to impaired serotonergic innervation of brain regions which are involved in the pathology of mood disorders. Thirdly, whether aspects of personality or temperament would be associated with preference for either a noradrenergic or serotonergic selective agent. Serotonergic effects on energy balance lead to secondary effects on glucose homeostasis, based on a well-established link between obesity and insulin resistance. Beside other monaminergic afferents, serotonergic innervation of basal ganglia may be disturbed and this may be causally related to structural changes in these nuclei. |
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