| 词汇 | renin |
| 释义 | BETA Examples of reninrenin isn’t in the Cambridge Dictionary yet. You can help! Changes in the renin-angiotensin-aldosterone axis with age are considered below. Effect of aging on renin activity and aldosterone excretion. Effect of ageing on renin activity and aldosterone excretion. Declining circulating renin and aldosterone levels lead to saltwasting and reduced blood volume. Diuretic therapy, the mainstay of treatment in chronic heart failure, leads to increased activation of the renin-angiotensin-aldosterone system. Sympathetic stimulation plays a significant part in activation of the renin-angiotensin-aldosterone system, exacerbating the tendency to retain salt and water. This loss of responsiveness is not present in the renin-angiotensin-aldosterone axis where the reflex is well-maintained into old age. Role of renin-angiotensin system in response to hemorrhage in fetal sheep. Plasma renin activity and aldosterone levels are normal or increased. Lloyd et al21 did not find significant changes in the activity of either renin measured in the plasma, or aldosterone. Activation of the sympathetic nervous system, renin release from the kidney and antidiuretic hormone release from the pituitary each add to salt and water retention seen in heart failure. Indirectly, secretion is also promoted by activation of the renin-angiotensin-aldosterone axis by a diminished effective arterial blood volume such as occurs in hypovolaemia, cirrhosis or congestive cardiac failure. Several authors have proposed that the primary event is expansion of the intravascular volume35 with chronic suppression of the renin-aldosterone system due to resetting of the sensors. The renin molecule contains both hydrophobic and hydrophilic amino acids. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Diuretic therapy for heart failure29 was pivotal until the role of the angiotensin-renin system was fully understood and able to be modified pharmacologically. When blood volume is low, juxtaglomerular cells in the kidneys activate their prorenin and secrete renin directly into circulation. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Another is renal artery stenosis, in which the reduced blood supply across the juxtaglomerular apparatus stimulates the production of renin. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Hopes of breakthrough appeared in 1982 when development of the second generation renin inhibitors began. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. |
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