| 词汇 | prion |
| 释义 | prion noun[ C ] medical specializeduk /ˈpraɪ.ɒn/ us /ˈpraɪ.ɑːn/ a small piece of protein that is thought to cause certain brain diseases, such as BSE and CJD朊病毒，蛋白侵染子（被认为会引起某些脑部疾病） Bacteria, moulds, germs & viruses abacterial acquired immune deficiency syndrome acquired immunodeficiency syndrome adenovirus aerobe amoeba bacteriology flora fly agaric germicidal germophobe gnotobiotic listeria microbe probiotic prokaryotic reindeer moss respiratory syncytial virus retroviral root rot Examples of prionprion Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state. Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro. Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. Influence of amino acid substitutions related to inherited human prion diseases on the thermodynamic stability of the cellular prion protein. Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits. This was the first time that the prion protein became ' visible ' - from a biochemist's point of view. Multiple folding pathways for heterologously expressed human prion protein. Normal prion protein has an activity like that of superoxide dismutase. Identification of glycoinositol phospholipid linked and truncated forms of the scrapie prion protein. Polymorphism in amyloid fibrils may account for the phenomenon of strains in mammalian prion diseases and in fungal prions. The selective neuronal targeting of prion strains has also been studied in experimental animals. Proteaseresistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity. Aggregates of scrapieassociated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state. Predicted -helical regions of the prion protein when synthesized as peptides from amyloid. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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