| 词汇 | oncogene |
| 释义 | oncogene noun[ C ] biology, medical specializeduk /ˈɒŋ.kəʊ.dʒiːn/ us /ˈɑːn.kə.dʒiːn/ a gene that is present in every cell and causes a healthy cell to become cancerous under particular conditions（致）癌基因 Genetics accession number adenine anaphase autosomal autosomally dizygotic genetically genetically engineered geneticist genic genomic genomics monozygotic mutate non-Darwinian non-familial non-genetic non-mutant nondominant sex-linked You can also find related words, phrases, and synonyms in the topics: Cancer Examples of oncogeneoncogene The cumulative inactivation of tumour suppressor genes and/or the amplification of oncogenes lead to progressively more malignant astrocytic tumours. Unravelling the molecular basis of oncogene co-operation has lagged far behind its conceptual realisation. These steps include inactivation of tumour suppressor genes and activation of oncogenes. These two nuclear proto-oncogenes encode proteins that play central roles in intracellular signal transduction pathways. In fact, the prolific field of signal transduction was born out of oncogene research. But, with a more-detailed knowledge about the signalling pathways that are influenced by oncogenes, this question is rapidly becoming a focus again. Most established cell lines are efficiently transformed by a single oncogene. By contrast, the activation of oncogenes is dominant in that a change in only one copy of the gene will have an effect. However, a strong synergism between the v-raf and v-myc oncogenes was revealed. Failure of these pathways can result in the loss of control over proliferation and lead to tumour development through the inactivation of tumour suppressor genes or the activation of oncogenes. His work on a particular oncogene is very important in developing new strategies to tackle the rogue cells of cancer. From the Hansard archive Example from the Hansard archive. Contains Parliamentary information licensed under the Open Parliament Licence v3.0 Loss of that methylation can induce the aberrant expression of oncogenes, leading to cancer pathogenesis. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. |
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