| 词汇 | misfolding |
| 释义 | BETA Examples of misfoldingmisfolding isn’t in the Cambridge Dictionary yet. You can help! Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. A high priority will be to assess whether drug candidates prevent the formation of oligomers, protofibrils or fibrils, and whether they reduce toxicity in animal models of misfolding diseases. Together, these findings underscore the important role of oxidative stress in various protein-misfolding disorders, and they suggest that antioxidants are reasonable therapeutic candidates in the treatment of these diseases. Protein misfolding: optional barriers, misfolded intermediates, and pathway heterogeneity. Two alternative misfolding hypotheses instead suggest that either tau protein or amyloid beta initiates the cascade. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. Several diseases are characterised by protein misfolding and aggregation. The mutation occurred in the gene encoding rhodopsin and induced an amino acid substitution known to result in misfolding of the protein. Misfolding errors and the barriers that they impose are probabilistic, not intrinsically coded into the pathway. A potential therapy for protein misfolding is to correct defective protein folding and trafficking using pharmacological chaperones. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. First, inhibition of early misfolding precludes a build-up of toxic oligomers or protofibrils. Protein aggregation and aggregate toxicity : new insights into protein folding, misfolding diseases and biological evolution. |
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