Examples of metronidazole

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Available evidence does not indicate involvement of cytosolic oxidoreductases in mechanisms of aerobic metronidazole resistance.
The most common triple therapy reported in the literature includes a combination of proton pump inhibitors with amoxicillin and claritromycin or claritromycin and metronidazole.
The main aim of treatment should be to prevent or eradicate infection, which may require systemic antibiotics, topical antimicrobials or metronidazole, or debridement.
The anti-trichomonal activity of metronidazole depends on its reductive activation mediated by ferredoxin in hydrogenosomes.
All patients were successfully treated with a single course of oral metronidazole.
The changes in levels of ferredoxin were insufficient to support ferredoxin deficiency as a cause of aerobic metronidazole resistance.
Correlation between aerobic and anaerobic resistance to metronidazole in trichomonads : application of new computer program for permutation tests.
Altogether these observations of differential toxicity of oxygen for drug-resistant and susceptible trichomonads indicate deficiencies in oxygen defence systems of the metronidazole-resistant trichomonads.
Down-regulation of ferredoxin expression accompanies development of the anaerobic type of metronidazole resistance.
Cases should be treated immediately with antibiotics (metronidazole and either penicillin or clindamycin) and antitoxin.
The most favorable results were achieved with proton pump inhibitors in combination with amoxicillin, claritromycin, and metronidazole (so-called triple therapy).
Should a caesarean section be performed, it is advisable also to cover anaerobes and so metronidazole should be added.
In the presence of metronidazole, ferredoxin preferentially provides electrons for reductive activation of the drug, resulting in the release of cytotoxic nitroradicals.
A so-called 'second hit' to the gut microflora occurs when the host is treated with metronidazole or vancomycin.
In conclusion, this comparative study demonstrated increased sensitivity to oxygen of the metronidazole-resistant trichomonads.
Therefore, we compared activities of this enzyme in the in vitro-developed metronidazole-resistant lines derived from a single drug-sensitive strain.
Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis.
Antimicrobial therapy is only an adjunct but should be appropriate and include anti-anaerobic cover with metronidazole and either clindamycin or penicillin.

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