irreversible
Medication overdoses killed one patient and irreversibly damaged the heart of another.
The minister's reputation suffered, possibly irreversibly.
This invention will irreversibly alter the world of communications.

SMART Vocabulary: related words and phrases

Not able to be changed
a leopard can't/doesn't change its spotsidiom
be no hard and fast rulesidiom
burn your boats/bridgesidiom
congenital
continuity
deep-seated
incorrigible
incurably
inelastic
inelasticity
inflexible
irreversible
irrevocable
irrevocably
leopard
sb's way or the highwayidiom
unchangeable
uncompromising
uncompromisingly
unredeemable

Examples of irreversibly

irreversibly
In addition, transient dehydration may irreversibly alter the structure of membrane proteins, particularly if they contain water-exposed domains.
During the same period, some 20 000 km2 of agricultural land were rendered irreversibly eroded and could not sustain further cropping.
Many of these ancient features could be easily and irreversibly damaged by human actions.
The metric used is the average annual carbon irreversibly allocated for each function, averaged over the life of the plant.
An open subsurface hydrothemal system will be easier to detect, mostly by vapor escape, but will lose molecules irreversibly to the polar cold trap.
However, when the man is irreversibly unconscious, the wife remains married unless she obtains a court order establishing otherwise.
On the contrary, if the resource base were irreversibly degraded, economic growth itself could be at risk.
This irreversibly permeabilizes the membrane to cations, depolarizing the cell to "0" membrane potential.
Cells in which either prazosin blocks the putative depolarization irreversibly or clonidine has little effect are grouped as depolarizing cells.
It is only when fluids are irreversibly mixed that chemical reactions occur.
This initially flickers, then undergoes transient and reversible opening and closing, and finally dilates irreversibly to allow for mixing of the aqueous contents.
Furthermore, imprudent use of the environmental resource base may irreversibly reduce the capacity for generating material production in the future.
During this process, the enzyme cyclooxygenase is irreversibly acetylated and inactivated.
Ovarian oestrogen production in premenopausal breast cancer patients can be irreversibly ablated with either oophorectomy or ovarian irradiation.
No differences could be detected, demonstrating that the protein was not irreversibly denatured by exposure to high temperature.
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