Examples of glioblastoma

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From a total of 480 brain slices from 26 mice, 55 were used for seeding glioblastoma cells.
This model could be used to study how glioblastoma tumour cells co-opt the host stromal cells to enhance tumour cell growth, survival, and invasion.
Typically, there is an increase in microvessel density and in the number of dilated large tortuous vessels in glioblastoma tumour biopsies.
Infiltrative tumors that closely resembled human glioblastomas developed in 100% of the animals by 10 days post injection.
Together, these observations indicate that human glioblastoma cells share similarities with neuronal progenitors and can mimic their motility in a brain-like environment.
In these studies, chemotherapy had no definitive impact on median or long-term survival of glioblastoma.
Thus, invading glioblastoma cells use neurite-like extensions to penetrate between neuronal fibers and contractile actin bundles for traction of the cell body.
In this study, we further identify and characterize tumor cells with stem cell properties in glioblastomas.
Evaluation of pre-radiotherapy cyclophosphamide in patients with newly diagnosed glioblastoma multiforme.
If this occurred in glioblastoma tumours it could be of importance therapeutically because normalisation of the vasculature may improve antitumour drug delivery and radiation effectiveness.
Specifically, temozolomide has been approved in combination with focal radiotherapy (concomitant phase) followed by up to six cycles of temozolomide monotherapy for adults with newly diagnosed glioblastoma.
The lack of a lymphatic system has been purported to be one reason for the lack of identified extracranial metastases in the vast majority of glioblastoma tumours.
The initial search strategy consisted of entering keywords 'temozolomide' and 'glioblastoma' or 'glioma', further refined by entering keyword 'radiotherapy'.
Actin stress fibers were also observed in glioblastoma cells injected into the brains of living mice.

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