| 词汇 | example_english_tumour-progression |
| 释义 | tumour progressioncollocation in Englishmeanings of tumourand progressionThese words are often used together. Click on the links below to explore the meanings. Or, see other collocations with progression. tumour noun[C] uk /ˈtʃuː.mər/ us /ˈtuː.mɚ/ a mass of diseased cells that might become a lump or ... See more at tumour progression noun[C or U] uk /prəˈɡreʃ.ən/ us /prəˈɡreʃ.ən/ the act of changing to the next stage ... See more at progression Examples of tumour progressionThese examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. The role of some of these molecules in tumourprogression has been evaluated in animal models and in patients. These results suggest that genetic and epigenetic changes in the tumour stroma alter epithelial - stroma interactions to support tumourprogression. The mechanism that links the level of tetraspanin expression to tumourprogression needs to be further investigated. Given its known biological roles in tumourprogression, galectin-1 has been postulated as an attractive target for anticancer therapies. Similarly, tumourprogression may result from the escape of recognition or attack by host defence mechanisms. The importance of neutrophil infiltration for tumourprogression has been validated in some animal models. Furthermore, neutrophils produce cytokines and proteases that could stimulate tumourprogression. This would make biological sense, since enhanced proliferation with associated migration occurs in tumourprogression, a clearly undesirable scenario. A booster dose may be considered for cases where there is tumourprogression or recurrence. It has been appreciated for some time that in response to neoplastic conversion in the adjacent epithelium, fibroblasts undergo changes that promote tumourprogression. Increased understanding of the molecular changes that occur during tumourprogression will allow us to identify potential antitumour targets for therapeutic interventions. Some of these genes might play important roles in gastric tumourprogression and could be immediately useful for prognosis and treatment stratification. Median time to tumourprogression was 206 days (7 months). It is clear that matrix-degrading proteases are essential for tumourprogression, but it is not known whether they all act in independent pathways or have some common downstream targets. Thus, galectin-1 expressed by tumour or stromal cells can favour tumourprogression through modulation of several mechanisms, including cell migration, adhesion, angiogenesis and tumour immune escape. Because each tumour type might express various antigens and develop different immunosuppressive mechanisms that could change with tumourprogression, the timing of some forms of immunotherapy may also become relevent. Tumourprogression is driven by inherited and acquired genetic changes, which are reflected in altered profiles of gene expression and of protein levels and modifications (fig001kpb). M2 macrophages are also believed to contribute to tumourprogression by performing the above functions through the release of growth factors, proangiogenic molecules and matrix-degrading enzymes. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. Want to learn more? Go to the definition of tumour Go to the definition of progression See other collocations with progression |
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