Examples of azathioprine

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Although methotrexate has understandably replaced azathioprine as potentially the best steroid-sparing agent, other drugs may also fulfil this role.
If systemic therapy is required, azathioprine or cyclophosphamide are usually needed as well as the prednisolone.
Other immunosuppressive agents such as azathioprine are frequently used.
Some patients need the addition of steroid-sparing agents like azathioprine, where prednisolone cannot be reduced below 10 mg/day.
If the benefit is insufficient, immunosuppression with prednisolone and azathioprine is often helpful.
In those who fail to respond, or who are intolerant of azathioprine, cyclosporin may be used.
Claims of a steroid-sparing effect had previously been made for azathioprine.
The exact effect of azathioprine is unknown but it is a derivate of 6-mercaptopurine, a cytotoxic agent that belongs to the antimetabolites.
Efficacy of azathioprine on multiple sclerosis new brain lesions evaluated using magnetic resonance imaging.
Some patients can eventually be maintained on azathioprine alone.
It may be possible, eventually, to withdraw prednisolone and to maintain the patient on azathioprine alone.
Persistent or life-threatening disease may require stronger immunosuppressive therapy, such as azathioprine, cyclophosphamide or cyclosporin.
Once stable, doses can be reduced and less toxic agents such as azathioprine or methotrexate may be substituted to maintain remission.
Steroid-sparing agents such as azathioprine or cyclophosphamide may be used.
Prednisolone and azathioprine, using the same regime described for myasthenia gravis, are effective and may lead to pharmacological remission.

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