| 词汇 | example_english_kinase-domain |
| 释义 | kinase domaincollocation in Englishmeanings of domainThese words are often used together. Click on the links below to explore the meanings. Or, see other collocations with domain. domain noun[C] uk /dəˈmeɪn/ us /doʊˈmeɪn/ an area of interest or an area over which a person ... See more at domain Examples of kinase domainThese examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. The kinasedomain is in equilibrium between an 'open, accessible ' state, subject to phosphorylation, and a 'closed, competent' state, able to perform catalysis. Within the tyrosine kinasedomain, further characteristic motifs can be found. W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinasedomain of the c-kit receptor. The net result is the phosphorylation of substrate molecules, either through a kinasedomain on the receptor itself or through activation of a protein kinase through second messenger pathways. The kinasedomain, while important for necroptotic (programmed necrotic) functions, it appears dispensable for other lethal, as well as pro-survival roles. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinasedomain. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. These receptors are known as dual-specificity kinases because their cytoplasmic kinasedomain has weak tyrosine kinase activity but strong serine/threonine kinase activity. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. When src is phosphorylated on a particular tyrosine, it folds on itself, and thus masks its own kinasedomain, and is thus turned off. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. This, in turn, causes a conformational change in the insulin receptor that activates the kinase domain residing on the intracellular portion of the beta subunits. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The alpha subunits have the catalytic kinasedomain. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinasedomain required for signaling. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. It lacks an intracellular serine/threonine protein kinasedomain and hence is a pseudoreceptor. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. That can mimic the activation loop phosphorylation and - by jumping all control steps at normal activation - immediately render the kinasedomain fully active. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinasedomain. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The encoded protein contains an amino-terminal kinasedomain, and a carboxy-terminal regulatory domain that mediates homodimerization. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. This member contains a nuclear targeting signal sequence, a protein kinasedomain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. The formation of such complex brings the two intracellular domains in close proximity to each other, eliciting initial trans-phosphorylation of each kinasedomain. From Wikipedia This example is from Wikipedia and may be reused under a CC BY-SA license. These examples are from corpora and from sources on the web. Any opinions in the examples do not represent the opinion of the Cambridge Dictionary editors or of Cambridge University Press or its licensors. Want to learn more? Go to the definition of domain See other collocations with domain |
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